Ryan Casteel was drafted by the Colorado Rockies in Round 17 of the 2010 MLB Draft.

He has played in the Minors since 2010 and is currently playing for the Mississippi Braves (AA) and is leading the team in home runs and RBIs as of July 2019.

He has played for 11 teams over the course of his career, including the Casper Ghosts (Rookie), the Tri-City Dust Devils (A), the Asheville Tourists (A), the Modesto Nuts (A), the Tulsa Drillers (AA), the Boise Hawks (A), the New Britain Rock Cats (AA), the Albuquerque Isotopes (AAA), the Jackson Generals (AA), the Arkansas Travelers (AA), and the Mississippi Braves (AA).